Endocrine Abstracts

Background: Vitamin D insufficiency (VDI) was reported to be associated with decreased insulin sensitivity (IS). Individuals with higher osteocalcin (OC) were shown to have better IS. Vitamin D regulates OC synthesis. Obese children carry an abnormal glucose homeostasis risk. Whether correction of VDI improves IS in obese children and mediates such effect via OC are unclear. We, therefore, studied glucose homeostasis, IS, vitamin D status and serum OC concentration in 230 obes...